Study of Solubility and Dissolution Rate of Stavudine Nanosuspension: Effect of Sonification Time

Pulla Reddy Institute of Pharmacy, Hyderabad, India

*Corresponding author: Dr. B Ravindra Babu, Pulla Reddy Institute of Pharmacy, Department of Pharmaceutics, Domadugu, Gummadidala (M), Sangareddy District, Telangana State, India, E-mail: [email protected]

Received Date: January 02, 2025

Published Date: January 28, 2025

Citation: Ravindra Babu B, et al. (2025). Study of Solubility and Dissolution Rate of Stavudine Nanosuspension: Effect of Sonification Time. Mathews J Pharma Sci. 9(2):47.

Copyrights: Ravindra Babu B, et al. © (2025).

ABSTRACT

This study focuses on enhancing the solubility and dissolution rate of Stavudine, an anti-HIV drug with poor water solubility and inconsistent bioavailability, by formulating it as a nanosuspension. The prepared nanosuspension demonstrates improved dissolution behavior compared to the marketed formulation. Characterization techniques such as transmission electron microscopy (TEM) and in vitro dissolution studies validate the formulation's effectiveness. Findings indicate that nanosuspensions significantly enhance drug absorption, offering a promising solution for poorly water-soluble drugs like Stavudine. Findings indicate that nanosuspensions significantly enhance drug absorption, offering a promising solution for poorly water-soluble drugs like Stavudine. This approach not only improves therapeutic efficacy but also facilitates dose reduction and minimizes side effects, highlighting its potential in pharmaceutical development.

Keywords: Stavudine Nanosuspension, Solubility Enhancement, Nanoprecipitation Method, Ultrasonication Techniques, Drug Delivery Systems, Bioavailability Improvement.