Prevention of Insulin Resistance by Herbal Compound from Fruit-Pulp of Eugenia jambolana in fructose fed rats

¹Department of Biochemistry, University College of Medical Sciences, University of Delhi, Delhi 110095, India

²School of Medicine, Washington University in Saint Louis, MO 63130, USA

³School of Medicine, Sharda University, Greater Noida, India

*Corresponding author: Reenu S Tanwar, Department of Biochemistry, University College of Medical Sciences, University of Delhi, Delhi 110095, India & School of Medicine, Washington University in Saint Louis, MO 63130, USA, Emails: [email protected]; [email protected]

Received Date: September 16, 2024

Published Date: October 24, 2024

Citation: Tanwar RS, et al. (2024). Prevention of Insulin Resistance by Herbal Compound from Fruit-Pulp of Eugenia jambolana in fructose fed rats. Mathews J Pharma Sci. 8(3):38.

Copyrights: Tanwar RS, et al. © (2024).

ABSTRACT

Aim: Present study was undertaken to investigate the preventive effect of active principle (FIIc) isolated from Eugenia jambolana on the development of insulin resistance induced by fructose in rats. Methodology: Crude aqueous extract of fruit-pulp of Eugenia jambolana was subjected to purification via Ion-exchange column chromatography that yielded FII which on further purification resulted FIIc. The purity of FIIc was tested by HPLC. FIIc was administered orally at a dose of 15 mg/kg b.wt. for 60 days to experimental rats. Body weight, blood glucose, serum triglyceride, total cholesterol, LDL-C, HDL-C, liver and muscle glycogen levels, TNF α, serum insulin, insulin resistance and insulinogenic index were estimated at the interval of 30 days up to a period of 60 days. Results: Fructose feeding for 60 days resulted significant (p<0.001) increase in serum biochemical parameters and decreased liver and skeletal muscle glycogen levels in untreated control. Administration of FIIc showed significant (p<0.001) reduction in blood glucose when compared with untreated control. Body weight, lipid profile and liver and skeletal muscle glycogen levels were significantly (p<0.001) improved after treatment with FIIc. Levels of serum TNF α and insulin were found to near normal following treatment with FIIc. Insulin resistance and insulinogenic index were significantly improved compared to untreated control. Conclusion: Our study showed that treatment with FIIc has a significant effect on fructose induced insulin resistance.

Keywords: Eugenia Jambolana, Insulin Resistance, Tumor Necrosis Factor α and Fructose.