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Previous Issues Volume 9, Issue 1 - 2025
Mucoadhesive Polymer-Based Formulations for Drug Delivery
Ezegbe Chekwube Andrew1,3,*, Anikwe Chidera Celestine4, Ezegbe Amarachi Grace2,#, Okafor Nnedimma Pauline1, Odo Kenechi Benjamin1, Onyia Oluebube Chisom1, Agu-kalu Amarachi1, Ugorji Anita Chidera1, Uchenna Chiamaka Precious1, Onoduagu Simeon Chinedu1, Dingwoke Juliet Obianuju1, Onyekwere Favour Ezinne1
1Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka, Nigeria
2Department of Home Science and Management, University of Nigeria, Nsukka, Nigeria
3Nanoscience and Advanced Materials, Graduate Program (PPG-Nano), Federal University of ABC, Avenida dos Estados, 5001, 09210-580, Santo Andre, Sao Paulo, Brazil
4Department of Clinical Pharmaceutical and Biological Sciences, University of Hertfordshire, England, United Kingdom
*Corresponding author: Ezegbe Chekwube Andrew, Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka, Enugu, Nigeria & Nanoscience and Advanced Materials, Graduate Program (PPG-Nano), Federal University of ABC, Avenida dos Estados, 5001, 09210-580, Santo Andre, Sao Paulo, Brazil, Tel: +2348038042802, Email: [email protected]
#Co-corresponding author: Ezegbe Amarachi Grace, Department of Home Science and Management, University of Nigeria, Nsukka, Enugu State, Nigeria, Tel: +2348061114433, E-mail: [email protected]
Received Date: February 06, 2025
Published Date: February 20, 2025
Citation: Andrew EC, et al. (2025). Mucoadhesive Polymer-Based Formulations for Drug Delivery. Mathews J Pharma Sci. 9(1):44.
Copyrights: Andrew EC, et al. © (2025).
ABSTRACT
Over the years, muco-adhesive systems, have been explored in order to obtain a controlled and efficient drug delivery. These systems also provide therapeutic benefits and increased retention time. Muco-adhesive polymers are biopolymers that adhere to the mucosal surface layer for an extended period of time. There are certain muco-adhesive systems that have the tendency to be easily eroded, tasteless and possess low cost. With these properties, they can reduce dosing frequency and also enhance patient safety. Although there are limitations that hinder the performance of muco-adhesive systems such as permeation and enzymatic barriers of the mucosa, these challenges could be overcome by research and development (R and D). The aim of this review was to elaborate on the different aspects of muco-adhesive polymers which include majorly the mechanisms, theories, principles and properties.
Keywords: Controlled Delivery, Drug Delivery, Muco-Adhesion, Retention Time.
