Influence of Several Excipients on Drug Release of Tablets Containing Resveratrol

¹ Beuth Hochschule fur Technik Berlin - University of Applied Sciences, Faculty of Mathematics-Physics-Chemistry, Pharmaceutical and Chemical Engineering, Luxemburger Str. 10, D-13353 Berlin, Germany

Corresponding Author: Mont Kumpugdee-Vollrath, Beuth Hochschule fur Technik Berlin - University of Applied Sciences, Faculty of Mathematics-Physics-Chemistry, Pharmaceutical and Chemical Engineering, Luxemburger Str. 10, D-13353 Berlin, Germany, 

Tel: +49-30-4504-2239; E-Mail: [email protected]

Received Date: 11 Apr 2016  
Accepted Date: 20 May 2016  
Published Date: 30 May 2016

Copyright © 2016 Kumpugdee-Vollrath M

Citation: Helmis M, Mohamad B and Kumpugdee-Vollrath M. (2016). Influence of Several Excipients on Drug Release of Tablets Containing Resveratrol. Mathews J Pharm Sci. 2(1): 007.

ABSTRACT:

For pharmaceutical tablet production, there are lots of commercial excipients available. All these excipients influence the drug release of tablet cores in different ways. In this project the influence of Carbopol 71G®, Carbopol 971P ®, Fujicalin ®, Neusilin US2 ®, Neusilin UFL2 ®, Pemulen TR-1 ®, Pemulen TR-2 ®, Sepistab ST 200 ® and Sepitrap 80 ® on drug release was investigated. Tablets were compressed with resveratrol as a model drug using an eccentric press. Tablets containing 2 wt.% of resveratrol which was mixed with a certain amount of excipient, in addition to 1 wt.% of talc, 1 wt.% magnesium stearate and Ludipress LCE. These products were compared with tablets without any excipients, but with all the other remaining components of the formulation. Drug release was in vitro investigated in dependence of time, according to European Pharmacopoeia (Ph. Eur. 2.9.3). It appeared that drug release depends on the qualities of the pharmaceutical additives. Tablets with Fujicalin ® and Sepistab ST 200 ® exhibit a rapid release and disintegration time, while the other pharmaceutical additives lead to a delayed release (retardation). Drug release kinetics was described by the mathematical model of Korsmeyer-Peppas.

KEYWORDS:

Fujicalin ®; Carbopol ®; Neusilin ®; Pemulen ®; Sepistab ®; Sepitrap ®; Resveratrol; in vitro; Drug Release.