Earwax Phenotype Related to A Risk Factor of Middle Ear Cholesteatoma

¹Department of Otorhinolaryngology, Juntendo University of Medicine, Shizuoka Hospital.²Department of Applied Biological Chemistry, Graduate School of Bioscience and Biotechnology, Chubu University.

³Department of Pharmacy, The University of Tokyo Hospital.

⁴Department of Otorhinolaryngology, Juntendo University of Medicine, Faculty of Medicine.

Corresponding Author: Takeshi Kusunoki, Department of Otorhinolaryngology, Juntendo University of Medicine, Shizuoka Hospital, 1129 Nagaoka Izunokuni-shi, Shizuoka 410-2295, Japan, 

Tel: +81-55-948-5088; EMail: [email protected]

Received Date: 17 Oct 2017  
Accepted Date: 24 Oct 2017  
Published Date: 25 Oct 2017

Copyright © 2017 Kusunoki T

Citation: Kusunoki T, Nakagawa H, Tsukamoto M, Toyoda Y, et all. (2017). Earwax Phenotype Related to A Risk Factor of Middle Ear Cholesteatoma. M J Otol. 1(1): 003.

ABSTRACT

In our study, the earwax phenotype of 40 patients with middle ear cholesteatoma was examined earwax in the healthy side and distant location from cholesteatoma by inspection. In our result, the middle ear cholesteatoma group was significantly higher in the incidence of wet earwax than in the healthy (control) group. In cases with bilateral middle ear cholesteatoma, the group with wet earwax showed a significantly higher incidence than those with dry earwax. Based on these and other data, the condition of wet earwax in the external ear canal appears to increase middle ear cholesteatoma. Concerning this mechanism, we considered that wet earwax could contribute to prolonging inflammation due to debris pooling in the tympanic recess together with the reduction in the self-cleansing function by the slow migration of wet earwax.

KEYWORDS

Earwax; Middle Ear Cholesteatoma; Abcc11.