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Previous Issues Volume 3, Issue 1 - 2018
Candidate Genes in Mexican Population with Diabetic Retinopathy
Perla M. Madrigal-Ruiz1,María Elena Aguilar-Aldrete2,Sergio Alberto Ramirez-Garcia3,Luis J. Flores-Alvarado1,Dalia A. Madrigal-Ruiz1,Rosalba Ruiz-Mejía1,Nory O. Dávalos-Rodríguez1
1Department of Molecular Biology and Genomic Medicine from University of Guadalajara, Jalisco, Mexico.
2Department of Public Health from University of Guadalajara, Jalisco Mexico.
3Institute of Research of Public Health of the University of the Sierra Sur, Oaxaca, México
Corresponding Author: Nory O. Dávalos-Rodríguez, Department of Molecular Biology and Genomic Medicine from University of Guadalajara, Jalisco, Mexico, Tel: +01(33) 1058-5200; E-Mail: [email protected]
Received Date: 03 Jan 2018
Accepted Date: 20 Jan 2018
Published Date: 22 Jan 2018
Copyright © 2018 Ramirez-Garcia SA
Citation: Madrigal-Ruiz PM, Aguilar-Aldrete ME, RamirezGarcia SA, Flores-Alvarado LJ, et al. (2018). Candidate Genes In Mexican Population with Diabetic Retinopathy. Mathews J Ophthalmol. 3(1): 019.
ABSTRACT
Diabetic retinopathy is a complex trait since it depends on environmental and genetic factors for its development. Among them, the early therapy with insulin, the degree of metabolic control, time evolution of diabetes and different genetic polymorphisms. We conducted an exhaustive search of the literature, and in the Mexican population we only found five genes associated with diabetic retinopathy; APOE, CYP19A1, ALR2, HLA-DR7, and ADRB3. We concluded that, considering the molecular heterogeneity of the DM2 and DR in Mexican population, is required more studies with candidate genes. A new frontier for research in DR, are the variant of the ELMO1, CUBN and LRP2 genes
KEYWORDS
Aldose Reductase; Apolipoprotein; Diabetic Retinopathy; Microvascular Complications; Polymorphism.
