Sex Does Matter. Assessing Magnesium and Calcium Nutritional Status with Hair Median Derivatives Bioassay

¹Aviva Polyclinic, Zagreb, Croatia

²Centar IGW, Zagreb, Croatia

^3,4Institute for Research and Development of the Sustainable Ecosystems (IRES), Zagreb, Croatia

*Corresponding author: Berislav MOMCILOVIC, Prof, MD, MSc, PhD, Institute for Research and Development of the Sustainable Ecosystems (IRES), Srebrnjak 59, 10000 Zagreb, Croatia; E-mail: [email protected].

Received Date: March 08, 2023

Published Date: March 20, 2023

Citation: MOMCILOVIC S, et al. (2023). Sex Does Matter. Assessing Magnesium and Calcium Nutritional Status with Hair Median Derivatives Bioassay. Mathews J Nutr Diet. 6(1):22.

Copyrights: MOMCILOVIC S, et al. © (2023).

ABSTRACT

Background: There is a need for a reliable biological indicator for assessing Mg and Ca nutritional status for precision personalized medicine. Objective: In this study, we used the long-term biological indicator tissue of hair to assess Mg and Ca nutritional status. Design: Hair Mg and Ca were analyzed in 1073 healthy white adult Caucasians [734 women (♀) and 339 men (♂)] with the ICP MS. The log-transformed data were analyzed with median derivatives bioassay. Results: The hair median values (µg∙g^-1) were W (♀) Mg 254 and M (♂) Mg 137.2 and W (♀) Ca 1721.4 and M (♂) Ca 492.0, respectively. The linear (adequate) range limiters of the sigmoid saturation curve for magnesium were W (♀) Mg 29.7–270.6 and M (♂) Mg 20.5–90.2, whereas these adequate range limits for calcium were W (♀) Ca 487.7–4456.8 and M (♂) Ca 26.1–816.4. The hair Mg/Ca ratio was stable in women but tends to grow from the start to the end of the linear adequate range segment for these two elements. Conclusions: Hair deposition of both Mg and Ca was about 2.5 times higher in the hair of women than in men. Hair median derivatives bioassay of Mg and Ca provides a reliable, non-invasive bio-indicator tissue for assessing their human nutritional status beyond the Recommended Dietary Allowances.

Keywords: Magnesium, Calcium, Hair; Sex, Nutritional status.