Long-term prognosis related to fasting total-cholesterol and triglyceride levels after TIA/stroke

Division of Neurology, Department of Medicine, Falun Hospital, S-791 82 Falun, Sweden

Corresponding Author: Sven-Erik Eriksson, Division of Neurology, Department of Medicine, Falun Hospital, S-791 82 Falun, Sweden

Received Date: Mar 10, 2019
Published Date: May 31, 2019
Copyright © 2019 Sven-Erik E
Citation: Sven-Erik E. (2019). Long-Term Prognosis Related to Fasting Total-Cholesterol and Triglyceride Levels After TIA/Stroke. Mathews J Neurol 4(1): 14.

ABSTRACT

Background and Aim: To identify statistically significant differences in the risk of (recurrent) stroke, myocardial infarction (MI), or mortality between groups with different levels of fasting total–cholesterol (TC) and triglyceride (TG).

Material and Methods: A total of 124 men and 96 women who were hospitalized in 1986 either at the Stroke Unit or Department of Neurology, Linköping, had their lipid levels assessed at admission and received follow-up retro-/prospectively until February 2011.

Results: Men had an almost linear correlation between increasing TC levels (< 5 mmol/L; 5-6.4 mmol/L; and ≥ 6.5 mmol/L), and increasing risk of MI during life, P = 0.016, and cardiovascular death (CVD) (not index stroke), P = 0.002; women had a U-shaped correlation. Men had an inverse correlation between TC levels and death due to cancer, P=0.008. Comparisons pairwise between sexes: TC 5-6.4 mmol/L, increased survival in women, P=0.038. According to Cox regression analyses, TC ≥ 6.5 mmol/L was a predictor of MI, and TG > 2.2 mmol/L had an unfavourable effect on survival.

Conclusions: TC and TG levels measured after admission effect men and women differently regarding the risk for MI and CVD. These differences of outcomes between sexes may support the fact that the indication for lipid-lowering treatment is partly dependent on sex.

Keywords: Total-Cholesterol; Fasting-Triglycerides; Recurrent Stroke; Myocardial Infarction; Cancer; Survival.