The Importance of Regulatory T Cells for the Tolerance Maintaining After Liver Transplantation

¹Department of Clinical Immunology, University Hospital Lozenetz, Sofia.

²Department of Pediatrics, University Hospital Lozenetz, Sofia.

³Department of Gastroenterology, University Hospital Lozenetz, Sofia.

⁴Intensive care Unit, University Hospital Lozenetz, Sofia.

⁵Department of Surgery, University Hospital Lozenetz, Sofia.

Corresponding Author: Tsvetelina Velikova, Clinical Immunology, University Hospital Lozenetz, 1 Kozyak str, 1407 Sofia.
Tel: +359883306049 ; E-Mail: [email protected]

Received Date: 06 Nov 2018  
Accepted Date: 08 Nov 2018  
Published Date: 12 Nov 2018

Copyright © 2018 Terzieva V

Citation: Terzieva V, Tsvetelina V, Antoaneta M, Yordanka U, et al. (2018). The Importance of Regulatory T Cells for the Tolerance Maintaining After Liver Transplantation. M J Immu. 2(1): 007. 

ABSTRACT

In some cases, spontaneous inhibition of immunological reactivity in transplantation, which is responsible for the graft rejection, has been observed, a phenomenon mediated by a specific T cell population defined as regulatory T cells (Tregs). This mini-review discusses the impact of Treg cells on the in initiation and maintenance of operational tolerance after liver transplantation, the Treg cells as a biomarker for post-transplantation tolerance assessment, and the novel approach of adoptive transfer of Treg cells after liver transplantation. Currently, the data are limited and do not allow for extensive comments. However, by virtue of the immunological background, Tregs are promising as diagnosing and therapeutic application that gives hope for successful liver transplantation.

KEYWORDS

T Regulatory Cells; Treg Cells; FoxP3; liver Transplantation; Operational Tolerance; Immunosuppressive Drugs.