Fibronectin as an Immunohistochemical Marker for Postmortem Diagnosis of Myocardial Infarction

¹Legal Medicine Organization of Iran, Kahrizak, Tehran, Iran.

²Pathology Department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

³Radiology Department, University of Pennsylvania, Philadelphia, USA.

Corresponding Author: Farid Azmoudeh-Ardalan, Pathology department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

 Tel: +98-912-1055232; E-Mail: [email protected]

Received Date: 13 Feb 2016   

Accepted Date: 14 Mar 2016   

Published Date: 22 Mar 2016

Copyright © 2016 Azmoudeh-Ardalan F

Citation: Azmoudeh-Ardalan F, Azmoudeh-Ardalan F, Eftekhari H, Haeri H, et al. (2016). Fibronectin as an Immunohistochemical Marker for Postmortem Diagnosis of Myocardial Infarction. M J Immu. 1(1): 001.

ABSTRACT

Acute myocardial infarction is sometimes a diagnostic dilemma in forensic pathology. Our aim is to evaluate the efficacy of fibronectin by immunohistochemical methods for diagnosis of early myocardial infarction in heart autopsies.Three groups of cases selected from autopsied hearts submitted to the pathology department of legal medicine organization of Iran during years 2004-2007 which included 15 cases of definite myocardial infarction (positive control group), 18 cases of noncardiac death (negative control group) and 26 cases suspicious of myocardial infarction based on clinical presentation just before death, presence of marked stenosis in at least one major coronary artery and exclusion of other causes of death (suspicious group). Fibronectin staining was performed on sections prepared from all of the cases.
With our proposed cut off value for fibronectin staining the sensitivity and specificity of this marker are 93.3% and 94.4%, respectively. This marker could also support the occurrence of myocardial infarction in 42% of our suspicious cases.We conclude that in spite of usefulness of this marker for detection of myocardial infarction, the results should be interpreted with caution.

KEYWORDS

Myocardial Infarction; Fibronectin; Autopsy; Histopathology.