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Previous Issues Volume 1, Issue 2 - 2016
Association Between Cumulative Time of Use of Antiretroviral Drugs and Vitamin D Deficiency in Brazilian Hiv-Infected Patients
Guilherme Almeida Rosa da Silva1, Filipe Anibal Carvalho Costa2, Walter de Araujo Eyer-Silva1, Jorge Francisco da Cunha Pinto1, Fernando Raphael de Almeida Ferry1, Marcelo Costa Velho Mendes de Azevedo1, Rogerio Neves Motta1
ABSTRACT
Objective: The objective of this study is to estimate the prevalence of vitamin D deficiency among HIV-infected outpatients treated at a university hospital in Brazil. Look for associations between vitamin D deficiency and factors such as age, sex, time since diagnosis, cumulative time of use of different antiretroviral count, CD4 + lymphocytes, and plasma viral load of HIV.
Design and Methods: We analyzed 125 patients aged above 18 years, of both sexes, who had recorded measurements of 25(OH)D, CD4+ lymphocyte count, and viral load count, all obtained in the same sample. Were excluded from the study any who had taken any vitamin supplement in the last year, carriers of chronic renal failure with creatinine clearance less than 30 ml/min, or liver failure. Linear regression was used to analyze continuous variables or Student`s t-test for categorical variables. The deficient patients were whose 25(OH)D concentrations were below 32 ng/dL.
Results: A total of 72.8% of patients had vitamin D deficiency. It was found no association between vitamin D and the variables: age, gender, time since diagnosis, duration of use of antiretroviral therapy, HIV viral load, and with none current antiretroviral regimen. A trend for the association was found between the plasma concentration of vitamin D and CD4+ lymphocyte count (negative β, R2 = 0.029, p = 0.058). There was a statistically significant association between the cumulative usage time of efavirenz and plasma concentrations of vitamin D (negative β, R² = 0.071 and p = 0.03).
