Perturbing Transsulfuration Pathway and Sulfur Recycling, A New Direction Towards Therapeutic Intervention of Inflammatory Bowel Disease

Corresponding Author: Sanjib Bhattacharyya, WPI-Advanced Institute for Materials Research (WPI-AIMR), Tohoku University, Sendai, Japan.
 Tel: +81-75-753-9864; E-mail:[email protected]

Received Date: 28 Mar 2016  
Accepted Date: 05 May 2016 
Published Date: 07 May 2016

Copyright © 2016 Bhattacharyya S

Citation:Bhattacharyya S. (2016). Perturbing Transsulfuration Pathway and Sulfur Recycling, A New Direction Towards Therapeutic Intervention of Inflammatory Bowel Disease. Mathews J Gastroenterol Hepatol 1(1): 001.

ABSTRACT

Combating inflammatory bowel disease (IBD) is becoming a growing challenge to the global health management. Our bowel can be envisioned as a big vessel reactor where millions of reactions occur at each moment, every day to meet the physiological demand of our body for quality control of our life. This includes the orchestration of several steps which ultimately funnel down to the intestinal system to drives the end point of the digestion process. Intestinal sulfur recycling by transsulfuration pathway can modulates the integrity of our bowel symptoms. Limiting the sulfur amino acid metabolism and mitigating hydrogen sulfide (H2S) generation can help to stabilize the colonic biochemistry with monitoring of metabolites for subsequent health risk assessment. Regulating protein sulfhydration in colonic tissue could play detrimental roles in the modulation of several contributing factors related to IBD.

KEYWORDS

Transsulfuration pathway; Hydrogen sulphide; Sulfhydration; Inflammatory bowel disease; Biomarkers; Therapy.