Gastrointestinal Stromal Tumor (GIST) Cecal in Pediatrics? Clinical Case

¹General Surgery Resident, General Surgery Service of Hospital General of Playa del Carmen, México

²Pediatric surgeon, General Surgery Service of Hospital General of Playa del Carmen, México

^3,6General surgeons, General Surgery Service of Hospital General of Playa del Carmen, México

^4,5Pathologists, General Surgery Service of Hospital General of Playa del Carmen, México

*Corresponding author: Guillermo Padrón-Arredondo, General Surgery Service of Hospital General of Playa del Carmen, Av. Constituyentes s/n with 35 Street, Col. Ejidal, Solidaridad Playa del Carmen, Q. Roo- PC: 77712, México, Tel: +52 984 876 2267, ORCID: 0000-0001-6049-5672; E-mail: [email protected].

Received Date: December 13, 2022

Published Date: December 31, 2022

Citation: Padrón-Arredondo G, et al. (2022). Gastrointestinal Stromal Tumor (GIST) Cecal in Pediatrics? Clinical Case. Mathews J Gastroenterol Hepatol. 7(1):17.

Copyrights: Padrón-Arredondo G, et al. © (2022).

ABSTRACT

Introduction: Gastrointestinal stromal tumors or GISTs are rare and occur mainly in the adult population, but a small percentage (1 to 2%) affect children and adolescents. GISTs are currently considered the most common mesenchymal neoplasm with a potential impact of around 1 to 1.5 cases per 100,000 inhabitants. Clinical Case: A 16-year-old female with no significant history of the case, began her condition with a month of evolution with postprandial fullness, occasional abdominal pain and hematuria. On physical examination it was globose at the expense of an intra-abdominal tumor of 40 x 50 cm of semisolid consistency, the rest of the examination without pathological data. Computed tomography reports “right ovarian tumor” measuring 21 x 22 x 14 cm. Normal laboratory studies. An exploratory laparotomy was performed, locating a tumor dependent on the cecum with implants in the adjacent peritoneum, an ectopic left kidney located in the left iliac fossa. Left hemicolectomy with side-to-side anastomosis is performed. Histopathological report reports spindle cell gastrointestinal stromal tumor with mild low-grade atypia (G1). Inflammatory (myoglandular) polyps with hyperplastic colonic mucosa florid with lymphoid follicles. Discussion: The best way to diagnose GISTs preoperatively is by fine-needle biopsy, although some fear that this system may spread tumors. Up to 85% of pediatric GISTs and 10-15% of adults do not contain the KIT or PDGFRA mutations and are classified as wild-type GISTs that are heterogeneous with respect to their clinical behavior and molecular profile.

Keywords: Gastrointestinal stromal tumors, Cecal, Pediatrics, CT.