There is an Association between Type 2 Diabetes Mellitus and the Presence of HSV-DNA in a Subset of Oral Fibroepithelial Polyp Patients in Sri Lanka: Preliminary Findings Need Confirmation

¹Alumni, School of Dentistry and Oral Health, Griffith University, Queensland, Australia

²Preventive Oral Health Unit, The National Dental Hospital (Teaching), Colombo, Sri Lanka

*Corresponding author: Manosha Lakmali Perera, Alumni, School of Dentistry and Oral Health, Griffith University, Queensland, Australia, Phone: +94 71 3271945, ORCID: 0000- 0001-7275- 2736, Email: [email protected]

Received Date: December 14, 2024

Published Date: February 07, 2025

Citation: Perera ML, et al. (2025). There is an Association between Type 2 Diabetes Mellitus and the Presence of HSV-DNA in a Subset of Oral Fibroepithelial Polyp Patients in Sri Lanka: Preliminary Findings Need Confirmation. Mathews J Diabetes Obes. 8(1):20.

Copyrights: Perera ML, et al. © (2025).

ABSTRACT

The relationship between Herpes Simplex Virus (HSV) and Type 2 Diabetes Mellitus (T2DM)remains uncertain. This study aimed to investigate the connection between type 2 diabetes and HSV positivity among male patients in Sri Lanka who present with oral fibroepithelial polyps. We collected samples of 25 fibroepithelial polyps patients from nine oro-maxillofacial units across six provinces in Sri Lanka. Tissue samples were taken from frozen excisional biopsies to prevent contamination and were tested for HSV-DNA using a real-time PCR assay. Data on sociodemographic information, clinical history, and current medical conditions were gathered through a pretested, interviewer-administered questionnaire. The results indicated that HSV-DNA was present in 44% of the samples, with 66.67% being HSV-1 and 33.33% being HSV-2. Interestingly, there was a statistically significant association between type 2 diabetes and the presence of herpes simplex viral DNA. The findings from this retrospective study warrant further investigation to validate the results and explore their implications in a larger sample size while controlling for confounding variables.

Keywords: Herpes Simplex Virus, Type 2 Diabetes, Hepertension,Periodontal Diseases, Inflammatory Metabolic Disease, Asymptomatic, Latency.