Periodontal Disease - Cancer Association and the Specific Role of Periodontal Disease in Lung Cancer Pathogenesis

Dental Surgeon (DDSc), Oncologist, Resident in Maxillofacial and Oral Surgery, 401 General Military Hospital of Athens, Athens, Greece

Corresponding Author: Nikolaos Andreas Chrysanthakopoulos, Dental Surgeon (DDSc), Oncologist, Resident in Maxillofacial and Oral Surgery, 401 General Military Hospital of Athens, Athens, Greece, Tel: +30-2610-225288; E-Mail: nikolaos_c@hotmail

Received Date: 22 Sep 2018  
Accepted Date: 24 Sep 2018   
Published Date: 28 Sep 2018
Copyright © 2018 Chrysanthakopoulos NA

Citation: Chrysanthakopoulos NA. (2018). Periodontal Disease - Cancer Association and the Specific Role of Periodontal Disease in Lung Cancer Pathogenesis. Mathews J Dentistry. 3(1): 018.

ABSTRACT

Several epidemiological studies have investigated the possible role of periodontal disease as a risk factor for systemic diseases such as cardiovascular disorders, diabetes mellitus, respiratory diseases such as Chronic Obstructive Pulmonary Disease, arterial hypertension, rheumatoid arthritis, endocrine disorders, allergies, osteoporosis, cancer, etc.. In recent years, the interest has focused on the potential role of periodontal disease in the cancer pathogenesis. Several case-control studies have recorded strong associations between several parameters/indices for assessing of periodontal disease, such as tooth loss, alveolar bone loss, probing pocket depth, clinical attachment loss, gingival index, bleeding on probing and oral cancer and those associations were retained after controlling for possible confounders, such as smoking, alcohol consumption and socio-economic status. Associations have also been reported between periodontal disease or its parameters with an increased risk for cancer in locations such as the tongue, oropharynx, breast, esophagus, stomach, kidney, pancreas, hematopoietic system, colon, prostate and uterus, however few studies have investigated the possible association between periodontal disease and lung cancer. Studies in this field show differences in design and methods regarding the conditions of the periodontal tissues, as well as on the collection of information on the systemic diseases that are under investigation.

KEYWORDS

Periodontal Disease; Cancer; Inflammation.