Study of the Hepatoprotective Activity of the Hydroethanolic Extract of the Roots of Cochlospermum tinctorium Perr. A. Rich in Wistar Rats

¹Histology, Biology of Reproduction, Cytogenetics and Medical Genetics Laboratory, Faculty of Health Sciences, University of Abomey-Calavi, Abomey-Calavi, Benin

²André Salifou University / Faculty of Health Sciences / Zinder National Hospital / Clinical Research and Health System Laboratory (LARECSS), Zinder, Niger

³Laboratory of Reference Hospital / Dan Dicko Dankoulodo University, Faculty of Health Sciences, Maradi, Niger

⁴Abdou Moumouni University / Faculty of Health Sciences / Laboratory of Histology-Embryology and Cellular Pathology “Pr Ag MOUMOUNI Hassane”, Niamey, Niger

*Corresponding author: Dr ISSA OUMAROU Boubacar Sidikou, André Salifou University, Faculty of Health Sciences, Zinder National Hospital, Clinical Research and Health System Laboratory (LARECSS), Zinder, Niger, Tel: (+227) 81013312, WhatsApp: (+227) 96728649; Email: [email protected]

Received Date: December 27, 2024

Published Date: January 21, 2025

Citation: Issa Oumarou BS, et al. (2025). Study of the Hepatoprotective Activity of the Hydroethanolic Extract of the Roots of Cochlospermum tinctorium Perr. A. Rich in Wistar Rats. Mathews J Cytol Histol. 9(1):30.

Copyrights: Issa Oumarou BS, et al. © (2025).

ABSTRACT

Title: Study of the Hepatoprotective Activity of the Hydroethanolic Extract of the Roots of Cochlospermum tinctorium Perr. A. Rich in Wistar Rats. Introduction: cochlospermum tinctorium Perr ex A Rich is a plant widely used by traditional African medicine. The main objective of our work is to study the hepatoprotective activity of the hydroethanolic extract of roots of cochlospermum tinctorium A rich. Material and Method: It was a prospective, descriptive and analytical study which took place over a period of 10 months from february to november 2021. We carried out a hydroethanolic extraction, then a phytochemical study of de the roots of cochlospermum tinctorium. To evaluate the hepatoprotective power in vivo of this extract, an animal model of toxicity induced by paracetamol in the wistar rat is used. The multiple comparisons are made by the ANOVA test. The differences are considered significant at p < 0, 05. Results: The extract showed a considerable hepatoprotective effect evidenced by a significant reduction in transaminases (ASAT, ALAT) and total bilirubin, an improvement in the tissue condition and hepatocyte morphology as well as reduction in signs of hepatic suffering resulting from intoxication with paracetamol. Conclusion: The results of study show that the hydroethanolic extracts of the roots of cochlospermum tinctorium protect the liver against attacks induced by paracetamol.

Keywords: Hepatoprotective, Cochlospermum tinctorium, Hydroethanolic Extract, Paracetamol.