Success with Crossmatch Positive Pancreas Transplants

Professor of Surgery, State University of New York, USA

*Corresponding author: Rainer WG Gruessner, Professor of Surgery, State University of New York, USA; Email: [email protected]

Received Date: October 24, 2023

Publication Date: December 14, 2023

Citation: Gruessner RWG, et al. (2023). Success with Crossmatch Positive Pancreas Transplants. Mathews J Case Rep. 8(11):140.

Copyright: Gruessner RWG, et al. © (2023)

SUMMARY

Crossmatch techniques have evolved over time from (cell-based) complement-dependent cytotoxicity to flow cytometry tests and, more recently, to virtual crossmatches. Since about 40% of all pancreas grafts in the United States are “imported” from a different UNOS region, virtual crossmatches have a clear advantage over cell-based crossmaches by lowering cold ischemia times and delayed graft function rates, both of which result in improved outcome. This review demonstrates that crossmatch positivity does not independently affect pancreas graft outcome, regardless of whether the crossmatch is T- or B-cell, current or historic. It also shows that hyperacute rejection is extremely rare in contrast to antibody-mediated rejection.

Keywords: Pancreas transplantation - Positive crossmatch