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Current Issue Volume 9, Issue 5 - 2024
Skene’s Gland Adenocarcinoma: A Rare Case Report of a PAX-8-Positive Female Urethral Adenocarcinoma and Literature Review
M Ait Alla1*, A Seffar2, G Hatim1, A Doumer2, H Talib1, T Chekrine1, Z Bouchbika1, N Benchakroun1, N Tawfiq1, H Jouhadi1, S Chaabi3, F Marnissi3, M Karkouri3, A Moataz2, M Dakir2, A Debbagh2, R Aboutaieb2, S Sahraoui1
1Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Morocco
2Department of Urology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Morocco
3Department of Pathology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Morocco
*Corresponding author: Meriem Ait Alla, Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Morocco, Phone: 00212669267662, Email: [email protected]
Received Date: April 21, 2024
Published Date: May 14, 2024
Citation: Alla MA, et al. (2024). Skene’s Gland Adenocarcinoma: A Rare Case Report of a PAX-8-Positive Female Urethral Adenocarcinoma and Literature Review. Mathews J Case Rep. 9(5):165.
Copyrights: Alla MA, et al. © (2024).
ABSTRACT
Background: Primary urethral carcinoma in females is scarce, with adenocarcinomas being rarer. To this date, there are several reported cases of urethral carcinomas in Women arising from Skene’s glands. Case report: We report the case of a 45-year-old woman, who presented with multiple urinary complaints: dysuria, haematuria, recurrent urinary tract infections and dyspareunia. Transvaginal examination showed bulging of the anterior wall of the vaginal wall. Computed tomography, magnetic resonance imaging (MRI), cystourethroscopy and the histopathological findings of the biopsied specimen revealed an adenocarcinoma of the urethra most likely at the starting point of the Skene’s glands with local extension and external iliac lymph nodes. We report the case of an intestinal-type primary urethral carcinoma caused probably by inflammation-related metaplasia in the urethral glands, which showed positive PAX-8 staining. To ensure accurate diagnosis, it's crucial to rule out other locations such as bladder, colorectal, and gynaecologic/mullerian cancers due to their specific immunophenotype. Written informed consent was obtained from the patient. Conclusion: Our study highlights the significance of imaging studies including endoscopic view and MRI findings of this rare disease. Multimodal therapy, including neoadjuvant chemoradiotherapy followed by surgery for optimal local and distant disease management.
Keywords: Skene Glands, Adenocarcinoma, Urethra, Case Report.
