Female with Glucose-6-Phosphate Dehydrogenase Deficiency Combined with Hereditary Spherocytosis

¹Cleveland Clinic South Pointe Hospital, Internal Medicine Residency, Warrensville Heights, OH, USA

²Ohio University Heritage College of Osteopathic Medicine, Cleveland Campus, Warrensville Heights, OH, USA

³Cleveland Clinic South Pointe Hospital, Taussig Cancer Center, Warrensville Heights, OH, USA

*Corresponding author: Nathan Reynolds, DO, MPH, Cleveland Clinic South Pointe Hospital, Internal Medicine Residency, Warrensville Heights, OH, USA, Phone: 2319207505, Email: [email protected]

Received Date: March 04, 2024

Published Date: May 07, 2024

Citation: Reynolds N, et al. (2024). Female with Glucose-6-Phosphate Dehydrogenase Deficiency Combined with Hereditary Spherocytosis. Mathews J Case Rep. 9(5):164.

Copyrights: Reynolds N, et al. © (2024).

ABSTRACT

G6PD deficiency is an x-linked recessive disease with abnormally low levels of glucose-6-phosphate dehydrogenase. As it is an X-linked disorder, the clinical manifestations of the disease are most commonly seen in males. However, heterozygous females can be affected in the presence of unfavorable lyonization. Hereditary spherocytosis is an inherited hemolytic anemia that results from a cytoskeletal defect in the red blood cell membrane. It is more commonly observed in North Americans and among people of northern European ancestry and is less commonly seen in African Americans or people of Southeast Asian ancestry. This case demonstrates an African American female patient with G6PD deficiency with a coexisting hereditary spherocytosis. To our knowledge, this is the first reported case of combined G6PD deficiency with hereditary spherocytosis in an African American female patient. Following basic ethical tenets, permission was obtained from the patient to write up and discuss this case and it was written in accordance with the Cleveland Clinic’s HIPAA De-Identification Policy.

Keywords: Glucose-6-Phosphate Dehydrogenase, Hereditary Spherocytosis