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Previous Issues Volume 9, Issue 1 - 2024
BCL2 a Hub Protein in Genes Expressed in Early Parkinsonism Patients
Rehab M Golam1,*, Islam M Tawfiq2, Asmaa Mohammed1
1Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, 63514, Egypt
2Medical student in Faculty of Medicine, Fayoum University, Fayoum, 63514, Egypt
*Corresponding Author: Rehab M Golam, Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, 63514, Egypt; Email: [email protected]
Received Date: December 25, 2023
Publication Date: January 16, 2024
Citation: Golam RM, et al. (2024). BCL2 a Hub Protein in Genes Expressed in Early Parkinsonism Patients. Mathews J Case Rep. 9(01):146.
Copyright: Golam RM, et al. © (2024)
ABSTRACT
Parkinson's disease is a neurodegenerative disorder affects approximately 10 million people the main pathological characteristics of PD are cell death in the brain's basal ganglia affecting the dopamine-secreting neurons in the substantia nigra. Method: We selected GSE6613 dataset from The Gene Expression Omnibus (GEO) it include (50) PD patients in early stages and (22) normal controls were present in the study the study was profiling gene expression from RNA extracted from patient blood .and used microarrays for data collection. Dataset was analyzed using the tool GEO2R then The 1st 300 gene of differentially expressed genes were analyzed in STRING to construct a network of the protein-protein interactions of the differentially expressed genes products with minimum required interaction score is set on high confidence 0,700. Results: nearly (1300) differentially expressed genes out of 21,000 are identified with p value lower than 0.05, then arranged the DEG in ascending manner and the 1st 300 gene were analyze by STRING tool and found that BCL2 and H3C12 hub proteins, The 2nd 300 gene analysis reveal that EGFR, PRKACA and H4C6 are hub proteins, The following 300 gene showed IL10, ESR1 and SNCA are hub proteins and the last 400 gene analysis showed MYC, RPL22, RPS27L, RPL35A and SKP1 are hub proteins. Conclusion: BCL2 is a hub protein between the 1st 300 significantly expressed gen in early PD patients ,Gene therapy and The CRISPR/Cas9 gene editing system can be directed to BCL2 that may modulate the path of the disease.
Keywords: Parkinson's disease, neurodegenerative, gene expression, BCL2
