Assessing Topical Phenytoin's Therapeutic Potential for Thermal Burn Regenerative Treatment

¹BDS, Junior Resident, Department of Oral & Maxillofacial Surgery, MGPGIDS, Puducherry, India

²Professor & Registrar (Academic), Head of IT Wing and Telemedicine, Department of Plastic Surgery & Telemedicine, JIPMER, Pondicherry
³Senior Resident, Department of Plastic Surgery, JIPMER, Puducherry, India

⁴Senior Resident, Department of Plastic Surgery, JIPMER, Puducherry, India

⁵Assistant Professor, Department of Plastic Surgery, JIPMER, Puducherry, India

*Corresponding author: Dr. Ravi Kumar Chittoria, MCh, DNB, MNAMS, FRCS (Edin), FRCS(Glasgow), FAMS, FTSI, FRSM, FACS, DSc, PhD, MBA, Senior Professor and Associate Dean (Academic), Head of IT Wing and Telemedicine, Department of Plastic Surgery and Telemedicine, JIPMER, India, Tel: +0992-03355663661, Email: [email protected]

Received Date: June 03, 2024

Published Date: July 04, 2024

Citation: Chittoria RK, et al. (2024). Assessing Topical Phenytoin's Therapeutic Potential for Thermal Burn Regenerative Treatment. Mathews J Case Rep. 9(6):173.

Copyrights: Chittoria RK, et al. © (2024).

ABSTRACT

Thermal burn injuries represent a significant burden, particularly in developing nations, where they inflict both physical and psychological trauma. Early wound healing promotion is critical to mitigate associated complications. Phenytoin, readily available, is recognized for its potential to expedite wound healing. This study aims to evaluate the healing effects of topical phenytoin on second and third-degree burn wounds. This study was performed in an 82 year old male who suffered with thermal burns. He underwent topical application of intravenous phenytoin solution every three days. Data collection encompassed demographic information, tissue culture results, wound discharge volume, pain severity, granulation tissue appearance, and wound contraction. Predominantly, burn wounds were self-inflicted. Initially colonized with pathogenic bacteria, the wounds demonstrated no impediment to phenytoin-induced healing. Following 3-5 phenytoin sessions, wound discharge significantly decreased, along with notable pain alleviation reported by patients. Digital planimetry revealed progressive wound contraction in all cases. Conclusion: Our findings suggest that topical phenytoin application fosters progressive wound contraction, re-epithelialization, reduced discharge, and pain relief, culminating in expedited wound healing. Some cases also exhibited a bacteriostatic effect. Further controlled trials are warranted to corroborate these observations.

Keywords: Topical Phenytoin Therapy, Regenerative Therapy, Wound Management.