Expression of E-cadherin and Ki-67 in Gastric Cancer Patients and Correlation with Clinicopathological Factors

¹Department of Medicine, Nassau University Medical Center, NY, USA.

²Department of Pathology, Hamadan University of Medical Sciences, Hamadan, Iran.

³Department of Medicine, Icahn School of Medicine at Mount Sinai Queens Hospital Center, NY, USA.

⁴Department of Oncology, Isfahan Milad Hospital, Isfahan, Iran.

Corresponding Author: Mahdis Solhjoo, Department of Medicine, Nassau University Medical Center, NY, USA, Tel: 15165720123; E-Mail:  [email protected]

Received Date: 29 Aug 2018  
Accepted Date: 05 Nov 2018  
Published Date: 12 Nov 2018

Copyright © 2018 Solhjoo M

Citation: Solhjoo M, Haghi AR, Golchin N, Golchin N, et al. (2018). Expression of E-cadherin and Ki-67 in Gastric Cancer Patients and Correlation with Clinicopathological Factors. Mathews J Cancer Sci. 3(1): 015.

ABSTRACT

Introduction: Gastric carcinoma is the second leading cause of cancer-related death in the world. The aim of this study is to evaluate the role of E-cadherin and Ki-67 expression in gastric cancer and their correlation with clinicopathological factors.

Materials and methods: In this study, gastric cancer patients who underwent total gastrectomy were selected and their pathologic slides evaluated by immunohistochemical analysis to assess E-cadherin and Ki-67 level. Additional data including lymph node involvement, tumor site, and depth were also considered.

Results: Total of 52 patients were considered. The most common diagnosis was adenocarcinoma (82.7%). E-cadherin was negative in 46.7% of the patients while Ki-67 was present in 76.4% of the cases. There was a significant relation between E-cadherin and lymph nodes involvement (p=0.021). There was a significant relation between Ki-67 and the cancer grade (p=0.035) and patient gender (p=0.003). However, no other significant differences between the study parameters were noticed.

Conclusions: In this study, E-cadherin level was related to the number of involved lymph nodes, and Ki-67 level was related to the cancer grade and patient gender.

KEYWORDS

Gastric Cancer; Ki-67; E-cadherin