Evaluation and Analysis of Colon Cancer in Kingdom of Bahrain: A Retrospective Study in a Tertiary Care Center

Salmaniya Medical Complex, Manama, Bahrain

*Corresponding Author: Dr. Safa Al Shaikh, Salmaniya Medical Complex, Manama, Bahrain. Tel: + 97 339 345 050 E-mail: [email protected]

Received Date: May 25, 2022

Published Date: July 26, 2022

ABSTRACT

Objectives: To provide an analysis for colorectal (CRC) cases including the incidence, pathological and molecular features for all cases that are diagnosed in a main tertiary hospital in Bahrain for the last four years. This will help in provide statistics about the incidence of colorectal cancer in Bahrain, also it will help in reducing the mortality and improving the patient prognosis by proper screening and genetic testing. Design: A Retrospective study. Materials and Methods: Data from our lab information system (LIS) was collected and analyzed for all patients diagnosed with colon cancer in Salmaniya Medical Complex for the period 2016-2019 and stratified according to the clinical information, histopathology and molecular testing results. Results: Between January 2016 and December 2019, 172 patients were diagnosed with colorectal carcinoma, 93 (54%) were males and 79 (46%) were females. The median age at presentation was 60 years. The most common mutated genes were TP53, KRAS, and APC genes. Limitations: The study included colorectal cancer cases that were only diagnosed by histopathology in Salmaniya Medical Complex. Patients without diagnostic biopsy or excision were not included in this study. Conclusion: Colorectal cancer presents at a younger age in Bahraini population. Due to lack of colorectal screening, we have a higher proportion of advanced stage cancer at presentation.

Keywords: Colorectal cancer, incidence, screening.