A Rare Case of Childhood Adrenocortical Carcinoma in a 4-Years-Old Female Child Presented with Features of Cushing Syndrome: Case Report and Literature Review

¹Division of Hematology and Oncology, Department of Pediatrics and Child Health, Addis Ababa University, Addis Ababa, Ethiopia

²Pediatric Endocrinology Unit, Department of Pediatrics and Child health, Addis Ababa University, Addis Ababa, Ethiopia

³Pediatrics Radiology Unit, Department of Radiology, Addis Ababa University, Addis Ababa, Ethiopia

*Correspondence: Gashaw Arega, Department of pediatrics and child health, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia; Tel: +251911417235 Email: [email protected]

Received Date: January 13, 2023

Publication Date: January 27, 2023

Citation: Arega G, et al. (2023). A Rare Case of Childhood Adrenocortical Carcinoma in a 4-Years-Old Female Child Presented with Features of Cushing Syndrome: Case Report and Literature Review. Mathews J Cancer Sci. 8(1):36.

Copyright: Arega G, et al. © (2023).

ABSTRACT

Childhood adrenocortical carcinoma is an extremely rare cancer with a poor prognosis. It usually presents during the first 5 years of life with a median age of 3–4 years, although there is a second smaller peak during the adolescence period. Here, we report a 4 – years-old female child diagnosed with childhood adrenocortical carcinoma with distant metastasis after she presented with features of Cushing syndrome and recent worsening of abdominal swelling of month duration. Chest and abdomen CT scan showed a left adrenal mass with liver and lung metastasis. Serum ACTH was low and serum cortisol was high.  Biopsy from the liver showed secondary deposits with malignant carcinoma. She started treatment with chemotherapy with EDP regimen with palliative intent. Despite chemotherapy she had progression of disease with systemic multiorgan involvement.

Keywords: Childhood adrenocortical carcinoma, Cushing syndrome, Distant metastasis, Edp regimen